Wnt-induced proteolytic targeting
نویسندگان
چکیده
منابع مشابه
Wnt-induced proteolytic targeting.
Misregulation of the Wnt pathway is a common route to cancer, including primary breast cancers. In this issue of Genes & Development, Miranda-Carboni and colleagues (3121-3134) demonstrate that the cyclin-dependent kinase inhibitor p27(Kip1) is ubiquitylated for proteasomal degradation in Wnt10b-induced mammary tumors exclusively by the Cul4A E3 ligase, which is strongly induced by Wnt signalin...
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The WNT signaling pathway has been of great interest to developmental biologists for decades and has more recently become a central topic for study in cancer biology. It is vital for cell growth and regulation of embryogenesis in many organ systems, particularly the CNS and its associated vasculature. We summarize the role of WNT in CNS development and describe how WNT signaling makes key contr...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2008
ISSN: 0890-9369
DOI: 10.1101/gad.1741008